Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 4/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | LAP3 | P28838 | 1/20 | 0.35 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14911148 | 0.90 | OPRK1 (0.44) | OPRK1CCR5CACNA1BTP53CYP2D6 | |
| SCHEMBL14911161 | 0.88 | OPRK1 (0.42) | OPRK1CACNA1BTP53CYP2D6CYP1A2 | |
| SCHEMBL1493572 | 0.86 | CACNA1B (0.38) | OPRK1PDE4ACACNA1BTP53CYP2D6 | |
| SCHEMBL1493571 | 0.86 | CACNA1B (0.38) | OPRK1PDE4ACACNA1BTP53CYP2D6 | |
| SCHEMBL14911147 | 0.82 | OPRK1 (0.47) | OPRK1CCR5CACNA1BCYP2D6CYP1A2 | |
| SCHEMBL22641456 | 0.79 | HSD11B1 (0.38) | PDE4ACACNA1BLMNACHRM2CHRM1 | |
| SCHEMBL2546331 | 0.79 | HSD11B1 (0.38) | PDE4ACACNA1BLMNACHRM2CHRM1 | |
| SCHEMBL12660590 | 0.78 | PDE4A (0.42) | OPRK1PDE4ATP53CYP2D6CYP1A2 | |
| SCHEMBL1491639 | 0.77 | CACNA1B (0.39) | OPRK1CACNA1BTP53 | |
| SCHEMBL1491637 | 0.77 | CACNA1B (0.39) | OPRK1CACNA1BTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130116318-A1 | Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116318-A1 | Enzyme Inhibitors | HDAC1, HDAC11, HDAC7 | OPRK1 4395/4885PDE4A 3300/4885CCR5 4788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.