Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 6/20 | 0.42 |
| ▸ | EZH1 | Q92800 | 2/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14727079 | 0.82 | EZH2 (0.40) | EZH2EZH1NR4A2MAPTKMT2A | |
| SCHEMBL2594002 | 0.80 | ERN1 (0.43) | EZH2EZH1NR4A2ALDH1A1MAPT | |
| SCHEMBL2588982 | 0.79 | EZH2 (0.40) | EZH2EZH1NR4A2CA12CA1 | |
| SCHEMBL2587259 | 0.76 | CA12 (0.37) | EZH2ALDH1A1MAPTKDM4ECA12 | |
| SCHEMBL2587361 | 0.76 | CA12 (0.35) | EZH2NR4A2ALDH1A1MAPTKDM4E | |
| SCHEMBL2592122 | 0.74 | CA12 (0.36) | EZH2EZH1CA12CA1CA2 | |
| SCHEMBL2592384 | 0.73 | LMNA (0.38) | EZH2EZH1ALDH1A1KDM4ECA12 | |
| SCHEMBL19621034 | 0.73 | CA12 (0.32) | EZH2ALDH1A1MAPTKDM4ECA12 | |
| SCHEMBL27979669 | 0.71 | PDGFRB (0.33) | EZH2EZH1ALDH1A1MAPTKDM4E | |
| SCHEMBL2591207 | 0.68 | NOTUM (0.37) | NR4A2ALDH1A1MAPTKDM4ECA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773754-A1 | METHOD OF TREATMENT | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013067296-A1 | METHOD OF TREATMENT | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (No 2) LIMITED (GB) | 2013-05-10 | — | — | WO | disclosed |