Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7117731 | 0.87 | NOS3 (0.48) | NOS3NOS1NOS2UHRF1SLC6A2 | |
| SCHEMBL28158261 | 0.84 | SLC6A2 (0.41) | NOS3NOS1NOS2UHRF1SLC6A2 | |
| SCHEMBL25652309 | 0.80 | LMNA (0.44) | NOS3NOS1NOS2SLC6A2SLC6A4 | |
| SCHEMBL23279739 | 0.79 | NOS3 (0.62) | NOS3NOS1NOS2KDM4EDHFR | |
| SCHEMBL30021400 | 0.79 | NOS3 (0.42) | NOS3NOS1NOS2KDM4EDHFR | |
| SCHEMBL25652154 | 0.79 | NOS3 (0.42) | NOS3NOS1NOS2UHRF1SLC6A2 | |
| SCHEMBL25652153 | 0.79 | NOS3 (0.42) | NOS3NOS1NOS2UHRF1SLC6A2 | |
| SCHEMBL317221 | 0.78 | UHRF1 (0.52) | NOS3NOS1NOS2UHRF1SLC6A2 | |
| SCHEMBL11616480 | 0.78 | UHRF1 (0.46) | NOS3NOS1NOS2UHRF1SLC6A2 | |
| SCHEMBL29707486 | 0.78 | UHRF1 (0.52) | NOS3NOS1NOS2UHRF1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112341390-B | Compound for preparing targeted histone methyltransferase EZH2 covalent inhibitor and preparation method and application thereof | 四川大学 | 2022-08-23 | — | — | CN | disclosed |
| CN-104066718-B | Substituted benzene compounds | EPIZYME股份有限公司 | 2017-08-29 | — | — | CN | disclosed |
| WO-2013067300-A1 | METHOD OF TREATMENT | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2013-05-10 | — | — | WO | disclosed |