Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14917792 | 0.97 | HDAC1 (0.53) | HDAC1HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL14917815 | 0.96 | HDAC1 (0.52) | HDAC1HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL14917884 | 0.96 | HDAC1 (0.52) | HDAC1HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL14918023 | 0.96 | HDAC1 (0.52) | HDAC1HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL14918585 | 0.93 | HDAC1 (0.55) | HDAC1HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL14919002 | 0.86 | HDAC4 (0.50) | HDAC1HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL14918459 | 0.84 | HDAC6 (0.48) | HDAC1HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL14918873 | 0.83 | HDAC1 (0.48) | HDAC1HDAC8HDAC6ALDH1A1MAPT | |
| SCHEMBL14918445 | 0.83 | ALDH1A1 (0.52) | HDAC1HDAC8HDAC6ALDH1A1MAPT | |
| SCHEMBL14918426 | 0.83 | HDAC1 (0.50) | HDAC1HDAC8HDAC6ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |