Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918772 | 0.87 | PDK1 (0.44) | HDAC6HDAC1HDAC8KDM4EALDH1A1 | |
| SCHEMBL14918374 | 0.87 | PDK1 (0.44) | HDAC6HDAC1HDAC8KDM4ESMN1; SMN2 | |
| SCHEMBL14917792 | 0.85 | HDAC1 (0.53) | HDAC6HDAC1HDAC8ALDH1A1KMT2A | |
| SCHEMBL14918961 | 0.85 | PDK1 (0.47) | KDM4EALDH1A1GLASMN1; SMN2PDK1 | |
| SCHEMBL14917815 | 0.84 | HDAC1 (0.52) | HDAC6HDAC1HDAC8ALDH1A1KMT2A | |
| SCHEMBL14918023 | 0.84 | HDAC1 (0.52) | HDAC6HDAC1HDAC8ALDH1A1KMT2A | |
| SCHEMBL14917884 | 0.84 | HDAC1 (0.52) | HDAC6HDAC1HDAC8ALDH1A1KMT2A | |
| SCHEMBL14917804 | 0.84 | HDAC1 (0.53) | HDAC6HDAC1HDAC8KDM4EALDH1A1 | |
| SCHEMBL14918747 | 0.83 | HDAC6 (0.48) | HDAC6HDAC1HDAC8KMT2AHDAC5 | |
| SCHEMBL14918585 | 0.81 | HDAC1 (0.55) | HDAC6HDAC1HDAC8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |