Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL14918037 | 0.92 | HDAC6 (0.48) | HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL14918111 | 0.84 | HDAC6 (0.63) | HDAC6HDAC1HDAC8 | |
| SCHEMBL14917670 | 0.82 | HDAC6 (0.53) | HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL14918456 | 0.80 | HDAC4 (0.55) | HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL14917969 | 0.79 | HDAC6 (0.50) | HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL12069976 | 0.78 | ADRB1 (0.46) | HDAC6HDAC1HDAC8HDAC4ADRB1 | |
| SCHEMBL14918373 | 0.76 | HDAC4 (0.55) | HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL14918477 | 0.76 | HDAC4 (0.70) | HDAC6HDAC8HDAC4 | |
| SCHEMBL14918156 | 0.75 | SMN1; SMN2 (0.53) | HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL14932826 | 0.75 | HDAC4 (0.68) | HDAC6HDAC1HDAC8HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066831-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |
| WO-2013066831-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |