Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.35 |
| ▸ | UGCG | Q16739 | 5/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598584 | 0.89 | GPR119 (0.51) | MAPTGPR119 | |
| SCHEMBL2598581 | 0.89 | GPR119 (0.51) | MAPTGPR119 | |
| Trifluoroacetic Acid SCHEMBL2598514 | 0.85 | UGCG (0.37) | GPR119NR1I2UGCGGPR6NOTUM | |
| Trifluoroacetic Acid SCHEMBL2597255 | 0.85 | UGCG (0.37) | GPR119NR1I2UGCGGPR6NOTUM | |
| SCHEMBL15022805 | 0.83 | TIPARP (0.37) | GPR119NR1I2UGCGGSK3BDYRK1A | |
| SCHEMBL15022808 | 0.83 | TIPARP (0.37) | GPR119NR1I2UGCGGSK3BDYRK1A | |
| SCHEMBL2598477 | 0.82 | SCD (0.39) | MAPK14NR1I2UGCGGSK3BDYRK1A | |
| SCHEMBL2598481 | 0.82 | SCD (0.39) | MAPK14NR1I2UGCGGSK3BDYRK1A | |
| SCHEMBL14917820 | 0.80 | HRH3 (0.38) | NR1I2UGCGGSK3BDYRK1AGPR6 | |
| SCHEMBL14918827 | 0.80 | HRH3 (0.38) | NR1I2UGCGGSK3BDYRK1AGPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256756-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA, INC. | 2014-09-11 | — | — | US | disclosed |
| WO-2013066869-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2013-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256756-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | GPR119, GPR139, GLP1R | MAPT 4846/4885GPR119 1/4885MAPK14 4276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.