Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 4/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918747 | 0.89 | HDAC6 (0.48) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918432 | 0.88 | HDAC8 (0.45) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918928 | 0.88 | HDAC4 (0.45) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918924 | 0.85 | HDAC1 (0.48) | HDAC6HDAC1HDAC8KMT2APDK1 | |
| SCHEMBL14918267 | 0.85 | MEN1 (0.60) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918039 | 0.84 | MEN1 (0.59) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918677 | 0.84 | MEN1 (0.59) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14917901 | 0.84 | MEN1 (0.59) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918059 | 0.84 | KMT2A (0.58) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918455 | 0.82 | HDAC6 (0.51) | HDAC6HDAC1HDAC8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |