Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14917901 | 0.99 | MEN1 (0.59) | MEN1KMT2AHDAC1HDAC6HDAC8 | |
| SCHEMBL14918039 | 0.99 | MEN1 (0.59) | MEN1KMT2AHDAC1HDAC6HDAC8 | |
| SCHEMBL14918677 | 0.99 | MEN1 (0.59) | MEN1KMT2AHDAC1HDAC6HDAC8 | |
| SCHEMBL14918059 | 0.97 | KMT2A (0.58) | MEN1KMT2AHDAC1HDAC6HDAC8 | |
| SCHEMBL14918404 | 0.93 | HDAC6 (0.56) | MEN1KMT2AHDAC1HDAC6HDAC8 | |
| SCHEMBL14917930 | 0.89 | MAPT (0.49) | MEN1KMT2AHDAC1HDAC6HDAC8 | |
| SCHEMBL14918142 | 0.88 | L3MBTL1 (0.48) | MEN1KMT2AHDAC1HDAC6HDAC8 | |
| SCHEMBL14918280 | 0.88 | L3MBTL1 (0.48) | MEN1KMT2AHDAC1HDAC6HDAC8 | |
| SCHEMBL14917904 | 0.88 | L3MBTL1 (0.48) | MEN1KMT2AHDAC1HDAC6HDAC8 | |
| SCHEMBL14919179 | 0.87 | MEN1 (0.47) | MEN1KMT2AHDAC1HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |