Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918432 | 0.90 | HDAC8 (0.45) | HDAC4HDAC6HDAC1MEN1KMT2A | |
| SCHEMBL14918364 | 0.88 | HDAC6 (0.52) | HDAC4HDAC6HDAC1MEN1KMT2A | |
| SCHEMBL14918924 | 0.88 | HDAC1 (0.48) | HDAC6HDAC1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL14917950 | 0.85 | HDAC1 (0.54) | HDAC4HDAC6HDAC1ALDH1A1MEN1 | |
| SCHEMBL14918455 | 0.84 | HDAC6 (0.51) | HDAC4HDAC6HDAC1ALDH1A1MEN1 | |
| SCHEMBL14918736 | 0.84 | HDAC1 (0.55) | HDAC4HDAC6HDAC1ALDH1A1MEN1 | |
| SCHEMBL14919162 | 0.84 | HDAC1 (0.55) | HDAC4HDAC6HDAC1ALDH1A1MEN1 | |
| SCHEMBL14918838 | 0.84 | HDAC1 (0.55) | HDAC4HDAC6HDAC1ALDH1A1MEN1 | |
| SCHEMBL14918938 | 0.84 | NPC1 (0.55) | HDAC4HDAC6HDAC1ALDH1A1MEN1 | |
| SCHEMBL14918896 | 0.84 | MEN1 (0.41) | HDAC4HDAC6HDAC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| US-8871770-B2 | Carboxamide compounds and methods for using the same | MIDCAP FINANCIAL TRUST | 2014-10-28 | — | — | US | disclosed |
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |