Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918855 | 0.99 | HDAC1 (0.55) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL14918903 | 0.99 | HDAC1 (0.55) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL14918844 | 0.99 | HDAC1 (0.55) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL14918743 | 0.97 | ALDH1A1 (0.56) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL14918438 | 0.92 | GAA (0.49) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL14918419 | 0.86 | HDAC4 (0.38) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL14918912 | 0.85 | HDAC4 (0.38) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL14918624 | 0.85 | HDAC4 (0.38) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL14918661 | 0.85 | HDAC4 (0.38) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL14919137 | 0.85 | HDAC6 (0.43) | HDAC1HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |