Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918120 | 0.93 | HDAC6 (0.47) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL14918073 | 0.91 | HPGDS (0.49) | HDAC6HDAC1HDAC5HDAC8HPGDS | |
| SCHEMBL14918802 | 0.90 | HDAC6 (0.55) | HDAC6HDAC1HDAC5HDAC8HPGDS | |
| SCHEMBL14918118 | 0.90 | HDAC6 (0.51) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL14918617 | 0.90 | HDAC6 (0.51) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL14917985 | 0.88 | HDAC6 (0.49) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL14918282 | 0.88 | HDAC6 (0.51) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL14918381 | 0.88 | HDAC6 (0.55) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL14918681 | 0.88 | HDAC6 (0.51) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL14917872 | 0.87 | HDAC6 (0.48) | HDAC6HDAC1HDAC5HDAC8HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066835-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |