Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Deoxiepinephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.83 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.83 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.83 |
| ▸ | TSHR | P16473 | 3/20 | 0.83 |
| ▸ | TP53 | P04637 | 2/20 | 0.83 |
| ▸ | THPO | P40225 | 2/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.83 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.83 |
| ▸ | LMNA | P02545 | 5/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | BLM | P54132 | 3/20 | 0.80 |
| ▸ | GFER | P55789 | 2/20 | 0.80 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.80 |
| ▸ | HPGD | P15428 | 2/20 | 0.80 |
| ▸ | GMNN | O75496 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.80 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Deoxiepinephrine SCHEMBL67772 | 0.91 | MAPT (1.00) | MAPTMAPK1HIF1AHSD17B10ALOX15 | |
| Deoxiepinephrine SCHEMBL29379200 | 0.91 | MAPT (1.00) | MAPTMAPK1HIF1AHSD17B10ALOX15 | |
| Deoxiepinephrine SCHEMBL31364234 | 0.89 | MAPT (1.00) | MAPTMAPK1HIF1AHSD17B10ALOX15 | |
| Deoxiepinephrine SCHEMBL7438678 | 0.89 | MAPT (0.96) | MAPTMAPK1HIF1AHSD17B10ALOX15 | |
| Deoxiepinephrine SCHEMBL1320882 | 0.89 | MAPT (1.00) | MAPTMAPK1HIF1AHSD17B10ALOX15 | |
| Deoxiepinephrine SCHEMBL6471632 | 0.87 | MAPT (0.92) | MAPTMAPK1HIF1AHSD17B10ALOX15 | |
| Dopamine SCHEMBL27987867 | 0.85 | MAPK1 (0.91) | MAPTMAPK1HIF1AHSD17B10ALOX15 | |
| Dopamine SCHEMBL18159501 | 0.85 | KDM4E (1.00) | MAPTMAPK1HIF1AHSD17B10ALOX15 | |
| Dopamine SCHEMBL9166387 | 0.85 | KDM4E (1.00) | MAPTMAPK1HIF1AHSD17B10ALOX15 | |
| Dopamine SCHEMBL8505 | 0.85 | KDM4E (1.00) | MAPTMAPK1HIF1AHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013067519-A2 | INSECT AND TICK G-COUPLED RECEPTORS USEFUL AS TARGETS FOR INSECTICIDES AND COMPOUNDS AND REAGENTS IDENTIFIED USING THE SAME | PURDUE RESEARCH FOUNDATION (US) | 2013-05-10 | — | — | WO | disclosed |