Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | DRD4 | P21917 | 2/20 | 1.00 |
| ▸ | DRD5 | P21918 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | APEX1 | P27695 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopamine SCHEMBL496657 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL30379944 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL8505 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL29362033 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL29375089 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL16685137 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL9166387 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL23704750 | 0.98 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL1873501 | 0.98 | KDM4E (0.95) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL1668345 | 0.98 | KDM4E (0.95) | KDM4EMAPTMAPK1TAAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9964552-B2 | Mass spectrometric identification and/or quantitation of catecholamines using aminopyrazoles | DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (SG) | 2018-05-08 | — | — | US | disclosed |
| US-20160305969-A1 | MASS SPECTROMETRIC IDENTIFICATION AND/OR QUANTITATION OF CATECHOLAMINES USING AMINOPYRAZOLES | DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (SG) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160305969-A1 | MASS SPECTROMETRIC IDENTIFICATION AND/OR QUANTITATION OF CATECHOLAMINES USING AMINOPYRAZOLES | AADAT, AASDHPPT, AANAT | KDM4E 1414/4885MAPT 2854/4885MAPK1 3276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.