Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | DRD4 | P21917 | 2/20 | 1.00 |
| ▸ | DRD5 | P21918 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | APEX1 | P27695 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopamine SCHEMBL496657 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL30379944 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL29362033 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL29375089 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL18159501 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL16685137 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL9166387 | 1.00 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL23704750 | 0.98 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL1873501 | 0.98 | KDM4E (0.95) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL1668345 | 0.98 | KDM4E (0.95) | KDM4EMAPTMAPK1TAAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 268986 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144903-A1 | RADIONUCLIDE-LABELED BORON-CONTAINING DRUG, AND PREPARATION AND USE THEREOF | Chengdu New Radiomedicine Technology Co., Ltd. (CN) | 2026-05-28 | — | — | US | claimed |
| US-20260146967-A1 | DEVICE AND SENSOR FOR DETECTION OF AN ANALYTE | REMINDED, INC. (US) | 2026-05-28 | — | — | US | claimed |
| US-20260146183-A1 | SUPRAMOLECULAR HYDROGEL FILM FOR REVERSIBLE ADHESION OF FROZEN FOOD, PRODUCTION METHOD, AND APPLICATION | NANJING AGRICULTURAL UNIVERSITY (CN) | 2026-05-28 | — | — | US | claimed |
| US-20260146298-A1 | INTESTINAL BIOMARKERS FOR GUT HEALTH IN DOMESTICATED BIRDS | INTERNATIONAL N&H DENMARK APS (DK) | 2026-05-28 | — | — | US | claimed |
| US-20260145003-A1 | OCULAR PHOTO-BIO-STIMULATION | NeuroRays, LLC (US) | 2026-05-28 | — | — | US | claimed |
| US-20260146992-A1 | INTESTINAL BIOMARKERS FOR GUT HEALTH IN DOMESTICATED BIRDS | INTERNATIONAL N&H DENMARK APS (DK) | 2026-05-28 | — | — | US | claimed |
| EP-4747627-A1 | METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS | Matterworks Inc (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122075805-A | Anticoagulation anti-infection dialysis catheter coating and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| US-12636371-B2 | Chemically coupled transporter for low-hydrophobicity bioactive drugs into the central nervous system | SKYBIO LLC (US) | 2026-05-26 | — | — | US | claimed |
| CN-115536753-B | Application of JWA polypeptide in preparation of anti-parkinsonism drugs | Suzhou Mingren Pharmaceutical Biotechnology Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| US-4042329-A | Method and device for detecting cholesterol | BECTON, DICKINSON AND COMPANY (US) | 1977-08-16 | — | — | US | claimed |
| US-4033997-A | Preparation of dopamine derivatives | ABBOTT LABORATORIES (US) | 1977-07-05 | — | — | US | claimed |
| US-4032406-A | MEASURING OXYGEN-UPTAKE VIA HYDROXYLATION OF DOPAMINE OR TYRAMINE; ASCORBATE, FUMARATE | MONSANTO COMPANY (US) | 1977-06-28 | — | — | US | claimed |
| US-4031242-A | INCREASED RENAL CIRCULATION | ABBOTT LABORATORIES (US) | 1977-06-21 | — | — | US | claimed |
| US-4011319-A | STIMULATING DOPAMINE RECEPTORS, RENAL VASODILATORS, DIURETICS | SMITHKLINE CORPORATION (US) | 1977-03-08 | — | — | US | claimed |
| US-3993436-A | Dyeing live hair with melanin precursors | SHISEIDO CO., LTD. (JA) | 1976-11-23 | — | — | US | claimed |
| US-3983234-A | CLOZAPINE | SANDOZ LTD. (CH) | 1976-09-28 | — | — | US | claimed |
| US-3964871-A | GLUCOSE OXIDASE, HORSERADISH PEROXIDASE | BECTON, DICKINSON AND COMPANY (US) | 1976-06-22 | — | — | US | claimed |
| US-3961060-A | DOPA, M-TYROSINE, APOMORPHINE, PIPERAZINE DERIVATIVE | ASTRA LAKEMEDAL AKTIEBOLAG (SW) | 1976-06-01 | — | — | US | claimed |
| US-3947590-A | Compositions and methods of increasing renal blood flow with gamma-glutamyl amide of dopamine | ABBOTT LABORATORIES (US) | 1976-03-30 | — | — | US | claimed |