Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4275441 | 0.86 | HDAC8 (0.57) | HSD11B1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL14919168 | 0.85 | SIGMAR1 (0.44) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL29920633 | 0.84 | HSD11B1 (0.48) | HSD11B1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL30538348 | 0.82 | ATM (0.64) | ATMSIGMAR1 | |
| SCHEMBL538735 | 0.82 | KMT2A (0.50) | HSD11B1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL29920628 | 0.81 | KDM4E (0.52) | HSD11B1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL620216 | 0.81 | KDM4E (0.52) | HSD11B1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL14918958 | 0.81 | HSD11B1 (0.59) | HSD11B1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL4352974 | 0.80 | KDM4E (0.57) | HSD11B1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL4346066 | 0.79 | HSD11B1 (0.45) | HSD11B1HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013067248-A1 | BENZOXAZINES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-05-10 | — | — | WO | disclosed |