Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMEL1 | Q495T6 | 3/20 | 0.46 |
| ▸ | MME | P08473 | 17/20 | 0.45 |
| ▸ | ACE | P12821 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18597832 | 1.00 | MMEL1 (0.46) | MMEL1MMEACERORC | |
| SCHEMBL14891060 | 1.00 | MMEL1 (0.46) | MMEL1MMEACERORC | |
| SCHEMBL18040125 | 0.90 | MME (0.55) | MMEACE | |
| SCHEMBL18724753 | 0.90 | MME (0.55) | MMEACE | |
| SCHEMBL16939240 | 0.90 | MME (0.55) | MMEACE | |
| SCHEMBL17980192 | 0.90 | MME (0.55) | MMEACE | |
| SCHEMBL12317504 | 0.89 | MME (0.45) | MMEL1MMEACERORC | |
| SCHEMBL14900472 | 0.86 | MMEL1 (0.51) | MMEL1MMEACERORC | |
| SCHEMBL12975259 | 0.84 | MMEL1 (0.47) | MMEL1MMEACERORC | |
| SCHEMBL14918910 | 0.83 | MME (0.55) | MMEL1MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773335-A1 | NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013067163-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2013-05-10 | — | — | WO | disclosed |