Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919787 | 0.83 | KMT2A (0.86) | GAAKMT2AMEN1GLATSHR | |
| SCHEMBL14919761 | 0.81 | KMT2A (1.00) | GAAKMT2AMEN1GLATSHR | |
| SCHEMBL8327880 | 0.77 | KMT2A (0.71) | GAAKMT2AMEN1GLATSHR | |
| SCHEMBL14919673 | 0.76 | KMT2A (0.71) | GAAKMT2AMEN1GLATSHR | |
| SCHEMBL14919337 | 0.76 | KMT2A (1.00) | GAAKMT2AMEN1GLATSHR | |
| SCHEMBL1332026 | 0.75 | KMT2A (0.62) | GAAKMT2AMEN1GLATSHR | |
| SCHEMBL14919706 | 0.75 | FTO (0.63) | GAAKMT2AMEN1GLATSHR | |
| SCHEMBL1333403 | 0.75 | COMT (0.63) | GAAKMT2AMEN1GLATSHR | |
| SCHEMBL8327919 | 0.74 | KMT2A (0.65) | GAAKMT2AMEN1GLATSHR | |
| SCHEMBL14919781 | 0.74 | KMT2A (0.70) | GAAKMT2AMEN1GLATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066469-A2 | KINASE INHIBITORS CAPABLE OF INCREASING THE SENSITIVITY OF BACTERIAL PATHOGENS TO B-LACTAM ANTIBIOTICS | SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2013-05-10 | — | — | WO | disclosed |