Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Actinoquinol SCHEMBL555260 | 0.85 | ALDH1A1 (0.62) | COMTKMT2AMEN1GLATSHR | |
| Actinoquinol SCHEMBL32668968 | 0.85 | ALDH1A1 (0.62) | COMTKMT2AMEN1GLATSHR | |
| SCHEMBL1332026 | 0.85 | KMT2A (0.62) | COMTKMT2AMEN1GLATSHR | |
| SCHEMBL14919706 | 0.85 | FTO (0.63) | COMTKMT2AMEN1GLATSHR | |
| Actinoquinol SCHEMBL3037156 | 0.84 | ALDH1A1 (0.61) | COMTKMT2AMEN1GLATSHR | |
| Actinoquinol SCHEMBL3037161 | 0.84 | ALDH1A1 (0.61) | COMTKMT2AMEN1GLATSHR | |
| Actinoquinol SCHEMBL1705425 | 0.84 | ALDH1A1 (0.61) | COMTKMT2AMEN1GLATSHR | |
| SCHEMBL15725524 | 0.82 | COMT (0.60) | COMTKMT2AMEN1GLATSHR | |
| SCHEMBL14601667 | 0.82 | COMT (0.77) | COMTKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL3246768 | 0.82 | KMT2A (0.53) | KMT2AMEN1GLATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4726304-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| US-20070015737-A1 | Compounds for inhibiting diseases and preparing cells for transplantation | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-01-18 | — | — | US | claimed |
| CN-1523992-A | Compositions and methods for treating amyloidosis | ʺ��ѧ | 2004-08-25 | — | — | CN | claimed |
| JP-2003517458-A | — | — | 2003-05-27 | — | — | JP | claimed |
| EP-1276483-A2 | COMPOSITIONS AND METHODS FOR TREATING AMYLOIDOSIS USING SULPHONATE DERIVATIVES | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2003-01-22 | — | — | EP | claimed |
| EP-1237547-A2 | COMPOUNDS FOR INHIBITING DISEASES AND PREPARING CELLS FOR TRANSPLANTATION | ISIS INNOVATION LIMITED (GB) | 2002-09-11 | — | — | EP | claimed |
| WO-2001003680-A2 | COMPOUNDS FOR INHIBITING DISEASES AND PREPARING CELLS FOR TRANSPLANTATION | ISIS INNOVATION LIMITED (GB) | 2001-01-18 | — | — | WO | claimed |
| WO-2000064420-A2 | COMPOSITIONS AND METHODS FOR TREATING AMYLOIDOSIS USING SULPHONATE DERIVATIVES | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2000-11-02 | — | — | WO | claimed |
| US-9763900-B2 | Chemical chaperonins as novel molecular modulators of beta protein aggregation present in conformational diseases | CENTRO DE NEUROCIENCIAS DE CUBA (CU) | 2017-09-19 | — | — | US | disclosed |
| US-20160106691-A1 | CHEMICAL CHAPERONINS AS NOVEL MOLECULAR MODULATORS OF BETA PROTEIN AGGREGATION PRESENT IN CONFORMATIONAL DISEASES | CENTRO DE NEUROCIENCIAS DE CUBA (NEURONIC) (CU) | 2016-04-21 | — | — | US | disclosed |
| US-20140329746-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2014-11-06 | — | — | US | disclosed |
| US-20140329746-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2014-11-06 | — | — | US | disclosed |
| US-8835654-B2 | Method and compositions for treating amyloid-related diseases | BHI LIMITED PARTNERSHIP (CA) | 2014-09-16 | — | — | US | disclosed |
| US-8835654-B2 | Method and compositions for treating amyloid-related diseases | BHI LIMITED PARTNERSHIP (CA) | 2014-09-16 | — | — | US | disclosed |
| EP-1227803-A2 | METHODS AND COMPOUNDS FOR INHIBITING AMYLOID DEPOSITS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001003680-A3 | COMPOUNDS FOR INHIBITING DISEASES AND PREPARING CELLS FOR TRANSPLANTATION | ISIS INNOVATION (GB) | 2002-07-11 | — | — | WO | disclosed |
| WO-2001003680-A2 | COMPOUNDS FOR INHIBITING DISEASES AND PREPARING CELLS FOR TRANSPLANTATION | ISIS INNOVATION LIMITED (GB) | 2001-01-18 | — | — | WO | disclosed |
| WO-2001003680-A2 | COMPOUNDS FOR INHIBITING DISEASES AND PREPARING CELLS FOR TRANSPLANTATION | ISIS INNOVATION LIMITED (GB) | 2001-01-18 | — | — | WO | disclosed |
| WO-2000071101-A2 | METHODS AND COMPOUNDS FOR INHIBITING AMYLOID DEPOSITS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2000-11-30 | — | — | WO | disclosed |
| WO-2000064420-A2 | COMPOSITIONS AND METHODS FOR TREATING AMYLOIDOSIS USING SULPHONATE DERIVATIVES | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2000-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329746-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | APP, PSEN1, PSEN2 | COMT 559/4885KMT2A 4192/4885MEN1 1011/4885 |
| US-20070015737-A1 | Compounds for inhibiting diseases and preparing cells for transplantation | IAPP, IDE, APP | COMT 2739/4885KMT2A 4686/4885MEN1 547/4885 |
| US-20160106691-A1 | CHEMICAL CHAPERONINS AS NOVEL MOLECULAR MODULATORS OF BETA PROTEIN AGGREGATION PRESENT IN CONFORMATIONAL DISEASES | HSPA2, HSPB1, HSP90AB2P | COMT 3796/4885KMT2A 4306/4885MEN1 4570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.