Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.39 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18444223 | 1.00 | MEN1 (0.42) | MEN1KMT2AALOX5PTGESALDH1A1 | |
| SCHEMBL14921393 | 1.00 | MEN1 (0.42) | MEN1KMT2AALOX5PTGESALDH1A1 | |
| SCHEMBL18444225 | 1.00 | MEN1 (0.42) | MEN1KMT2AALOX5PTGESALDH1A1 | |
| SCHEMBL14921296 | 1.00 | MEN1 (0.42) | MEN1KMT2AALOX5PTGESALDH1A1 | |
| SCHEMBL18444222 | 1.00 | MEN1 (0.42) | MEN1KMT2AALOX5PTGESALDH1A1 | |
| SCHEMBL30511498 | 0.91 | ALOX5 (0.41) | MEN1KMT2AALOX5PTGESALDH1A1 | |
| SCHEMBL17550484 | 0.89 | BTN3A1 (0.40) | MEN1KMT2AALOX5PTGESALDH1A1 | |
| SCHEMBL30583779 | 0.88 | MEN1 (0.42) | MEN1KMT2AALOX5PTGESALDH1A1 | |
| SCHEMBL16258629 | 0.88 | MEN1 (0.42) | MEN1KMT2AALOX5PTGESALDH1A1 | |
| SCHEMBL16258631 | 0.88 | MEN1 (0.42) | MEN1KMT2AALOX5PTGESALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776438-A1 | SUBSTITUTED PURINE NUCLEOSIDES, PHOSPHORAMIDATE AND PHOSPHORDIAMIDATE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS | Inhibitex, Inc. (US) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013070887-A1 | SUBSTITUTED PURINE NUCLEOSIDES, PHOSPHORAMIDATE AND PHOSPHORDIAMIDATE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS | INHIBITEX, INC. (US) | 2013-05-16 | — | — | WO | disclosed |
| WO-2013066991-A1 | CRYSTALLINE SOLVATES OF NUCLEOSIDE PHOSPHOROAMIDATES, THEIR STEREOSELECTIVE PREPARATION, NOVEL INTERMEDIATES THEREOF, AND THEIR USE IN THE TREATMENT OF VIRAL DISEASE | INHIBITEX, INC. (US) | 2013-05-10 | — | — | WO | disclosed |