Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | LMNA | P02545 | 7/20 | 0.65 |
| ▸ | TSHR | P16473 | 5/20 | 0.65 |
| ▸ | HTT | P42858 | 5/20 | 0.65 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919808 | 0.88 | ALDH1A1 (0.67) | ALDH1A1LMNATSHRHTTMCOLN3 | |
| SCHEMBL29424351 | 0.79 | TSHR (1.00) | ALDH1A1LMNATSHRHTTMCOLN3 | |
| SCHEMBL14919519 | 0.78 | ALDH1A1 (0.75) | ALDH1A1LMNATSHRHTTMCOLN3 | |
| SCHEMBL14919843 | 0.77 | GAA (0.74) | ALDH1A1LMNATSHRHTTMCOLN3 | |
| SCHEMBL14919572 | 0.76 | LMNA (0.77) | ALDH1A1LMNATSHRHTTMCOLN3 | |
| SCHEMBL14919738 | 0.73 | TSHR (0.55) | ALDH1A1LMNATSHRHTTMCOLN3 | |
| SCHEMBL3038166 | 0.73 | ALDH1A1 (0.55) | ALDH1A1TSHRPOLB | |
| SCHEMBL14919797 | 0.73 | ALDH1A1 (0.72) | ALDH1A1LMNATSHRHTTMCOLN3 | |
| SCHEMBL14919658 | 0.72 | MAPT (0.68) | ALDH1A1LMNATSHRHTTMCOLN3 | |
| SCHEMBL14919704 | 0.71 | ALDH1A1 (0.49) | ALDH1A1LMNATSHRHTTMCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066469-A2 | KINASE INHIBITORS CAPABLE OF INCREASING THE SENSITIVITY OF BACTERIAL PATHOGENS TO B-LACTAM ANTIBIOTICS | SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2013-05-10 | — | — | WO | disclosed |