Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | SLC40A1 | Q9NP59 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | FABP4 | P15090 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14920008 | 0.88 | POLB (0.64) | POLBKMT2AMEN1SLC40A1ALDH1A1 | |
| SCHEMBL14919509 | 0.83 | KMT2A (0.65) | POLBKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL14919481 | 0.82 | POLB (0.68) | POLBKMT2AMEN1SLC40A1ALDH1A1 | |
| SCHEMBL14919803 | 0.81 | POLB (0.67) | POLBKMT2AMEN1SLC40A1ALDH1A1 | |
| SCHEMBL14919833 | 0.79 | TSHR (0.60) | POLBKMT2AMEN1SLC40A1ALDH1A1 | |
| SCHEMBL14919801 | 0.79 | POLB (0.59) | POLBKMT2AMEN1SLC40A1ALDH1A1 | |
| SCHEMBL14919795 | 0.78 | POLB (0.58) | POLBKMT2AMEN1SLC40A1ALDH1A1 | |
| SCHEMBL14919916 | 0.77 | ALDH1A1 (0.61) | POLBKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL14919775 | 0.77 | ALDH1A1 (0.82) | POLBKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL22095985 | 0.77 | ALDH1A1 (0.73) | KMT2AMEN1ALDH1A1HSD17B10FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066469-A2 | KINASE INHIBITORS CAPABLE OF INCREASING THE SENSITIVITY OF BACTERIAL PATHOGENS TO B-LACTAM ANTIBIOTICS | SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2013-05-10 | — | — | WO | disclosed |