Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28184932 | 0.87 | F2RL1 (0.53) | F2RL1TAAR1SMN1; SMN2ALOX5CALM1 | |
| SCHEMBL16892959 | 0.83 | F2RL1 (0.53) | F2RL1TAAR1SMN1; SMN2ALOX5CALM1 | |
| SCHEMBL14920624 | 0.82 | TAAR1 (0.54) | TAAR1PARP1 | |
| SCHEMBL27957913 | 0.80 | AR (0.47) | ARSMN1; SMN2ALDH1A1 | |
| SCHEMBL20589395 | 0.79 | F2RL1 (0.49) | ARF2RL1TAAR1SMN1; SMN2ALOX5 | |
| SCHEMBL8939115 | 0.79 | TAAR1 (0.53) | F2RL1TAAR1SMN1; SMN2CALM1MAOB | |
| SCHEMBL1236959 | 0.77 | CALM1 (0.53) | F2RL1SMN1; SMN2ALOX5CALM1ALDH1A1 | |
| SCHEMBL3797481 | 0.75 | TAAR1 (0.59) | F2RL1TAAR1CALM1MAOBCA1 | |
| SCHEMBL1754089 | 0.75 | TAAR1 (0.57) | F2RL1TAAR1SMN1; SMN2CALM1MAOB | |
| SCHEMBL6121859 | 0.75 | CA1 (0.48) | F2RL1TAAR1SMN1; SMN2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788326-A1 | N-(PYRID-4-YL)AMIDES AND N-(PYRIMIDIN-4-YL)AMIDES AND THEIR PHARMACEUTICAL AND COSMETIC USE | Galderma Research & Development (FR) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013064681-A1 | N-(PYRID-4-YL)AMIDES AND N-(PYRIMIDIN-4-YL)AMIDES AND THEIR PHARMACEUTICAL AND COSMETIC USE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2013-05-10 | — | — | WO | disclosed |