Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10650774 | 0.89 | CALM1 (0.59) | TAAR1CALM1HRH3F2RL1MAOB | |
| SCHEMBL22589949 | 0.85 | HRH3 (0.49) | HRH3 | |
| SCHEMBL1754089 | 0.83 | TAAR1 (0.57) | TAAR1CALM1HRH3F2RL1MAOB | |
| SCHEMBL20610769 | 0.81 | F2RL1 (0.66) | F2RL1SMN1; SMN2 | |
| SCHEMBL11572302 | 0.81 | HRH3 (0.56) | HRH3 | |
| SCHEMBL3797481 | 0.80 | TAAR1 (0.59) | TAAR1CALM1F2RL1MAOBSIGMAR1 | |
| SCHEMBL6993852 | 0.79 | CALM1 (0.49) | TAAR1CALM1F2RL1MAOBSMN1; SMN2 | |
| SCHEMBL11132376 | 0.79 | IDO1 (0.50) | TAAR1CALM1SMN1; SMN2ALOX15AOC3 | |
| SCHEMBL14920751 | 0.79 | AR (0.51) | TAAR1CALM1F2RL1MAOBSMN1; SMN2 | |
| SCHEMBL13359300 | 0.78 | TAAR1 (0.52) | TAAR1CALM1HRH3F2RL1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508310-A | ADMINISTERING SUBSTITUTED ALDEHYDES OR KETONES WHICH CAN REACT WITH T-CELL SURFACE GROUPS TO FORM SCHIFF BASES | BURROUGHS WELLCOME CO. (US) | 1996-04-16 | — | — | US | disclosed |
| US-4751246-A | ALPHA(AMINOALKYL)-4-HYDROXY-3-(ALKYLSULFINYL) BENZENEMETHANOL AND 2-(4-HYDROXY-3-(ALKYLSULFINYL) PHENYL)ETHYLAMINE-HYPOTENSIVE AGENTS | STERLING DRUG INC. (US) | 1988-06-14 | — | — | US | disclosed |
| US-4695589-A | HYPOTENSIVE AGENTS | STERLING DRUG INC. (US) | 1987-09-22 | — | — | US | disclosed |
| EP-0047536-B1 | SUBSTITUTED PROPYLAMINES | ELI LILLY AND COMPANY (US) | 1984-06-27 | — | — | EP | disclosed |
| US-4452816-A | HYPOTENSIVE AND ANTIARRHYTHMIA AGENTS | STERLING DRUG INC. (US) | 1984-06-05 | — | — | US | disclosed |
| EP-0007206-B1 | PHENETHANOLAMINES, THEIR FORMULATIONS, PREPARATION AND USE | ELI LILLY AND COMPANY (US) | 1983-02-23 | — | — | EP | disclosed |
| US-4374149-A | HYPOTENSIVE AGENT AND VASODILATOR | STERLING DRUG INC. (US) | 1983-02-15 | — | — | US | disclosed |
| EP-0047536-A2 | Substituted propylamines | ELI LILLY AND COMPANY (US) | 1982-03-17 | — | — | EP | disclosed |
| EP-0007206-A1 | Phenethanolamines, their formulations, preparation and use | ELI LILLY AND COMPANY (US) | 1980-01-23 | — | — | EP | disclosed |