Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 5/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14922263 | 0.84 | ADRB1 (0.55) | HRH3HPGDKCNH2HTR1AHTR1D | |
| SCHEMBL8275460 | 0.83 | HRH3 (0.59) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL22022308 | 0.81 | HRH3 (0.61) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL14922313 | 0.80 | HRH3 (0.57) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL16218812 | 0.80 | DRD2 (0.59) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL21659428 | 0.80 | HRH3 (0.68) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL14922320 | 0.80 | HRH3 (0.52) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL8363114 | 0.80 | HRH3 (0.63) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL14922311 | 0.79 | HRH3 (0.56) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL21659290 | 0.78 | HRH3 (0.79) | HRH3MAPTHPGDKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE44205-E1 | Adenosine A2a receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-05-07 | — | — | US | disclosed |
| US-RE44205-E1 | Adenosine A2a receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-05-07 | — | — | US | disclosed |