Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537996 | 0.87 | EPHX2 (0.41) | KDM4EALDH1A1MAPK1TDP1GAA | |
| SCHEMBL7399474 | 0.73 | CYP2D6 (0.38) | ALDH1A1TDP1GAAMEN1KMT2A | |
| SCHEMBL27428507 | 0.73 | KDM4E (0.33) | KDM4EALDH1A1TDP1EPHX2TSHR | |
| SCHEMBL31226873 | 0.70 | EPHX2 (0.44) | TDP1GAAMEN1KMT2AEPHX2 | |
| SCHEMBL1554908 | 0.70 | EPHX2 (0.40) | TDP1GAAMEN1KMT2AEPHX2 | |
| SCHEMBL29042242 | 0.70 | MAPT (0.54) | KDM4EALDH1A1LMNAMAPTEPHX2 | |
| SCHEMBL3427025 | 0.69 | — | — | |
| SCHEMBL3429375 | 0.69 | — | — | |
| SCHEMBL4291254 | 0.69 | — | — | |
| SCHEMBL3283920 | 0.69 | PKM (0.42) | KDM4EALDH1A1MAPK1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966217-B1 | NOVEL, ACYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER IP GMBH (DE) | 2013-05-08 | — | — | EP | disclosed |