SCHEMBL14924735

SCHEMBL14924735

CNc1cccc(NC(=O)c2cc(C(=O)Nc3cccc(NC)c3)cc(C(=O)Nc3cccc(NC(=O)Cl)c3)c2)c1

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ KCNK3 O14649 5/20 0.54
▸ KCNK9 Q9NPC2 5/20 0.54
▸ TOP1 P11387 2/20 0.54
▸ TOP2A P11388 1/20 0.54
▸ TOP2B Q02880 1/20 0.54
▸ MEN1 O00255 7/20 0.53
▸ KMT2A Q03164 7/20 0.53
▸ RXFP1 Q9HBX9 2/20 0.53
▸ KCNH2 Q12809 1/20 0.53
▸ POLB P06746 1/20 0.49
▸ SIRT1 Q96EB6 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17013407 0.86 KCNK3 (0.69) KCNK3KCNK9TOP1MEN1KMT2A
SCHEMBL18934622 0.86 TOP1 (0.44) KCNK3KCNK9TOP1TOP2ATOP2B
SCHEMBL24193768 0.85 KMT2A (0.57) KCNK3KCNK9TOP1TOP2ATOP2B
SCHEMBL12383062 0.83 KMT2A (0.58) KCNK3KCNK9TOP1TOP2ATOP2B
SCHEMBL1630322 0.82 KMT2A (0.63) KCNK3KCNK9MEN1KMT2ARXFP1
SCHEMBL23577148 0.81 KCNK3 (0.82) KCNK3KCNK9MEN1KMT2APOLB
SCHEMBL19829331 0.81 MEN1 (0.67) KCNK3KCNK9MEN1KMT2ARXFP1
SCHEMBL11161409 0.80 GPR35 (0.58) KCNK3KCNK9TOP1TOP2ATOP2B
SCHEMBL13256343 0.80 KMT2A (0.54) KCNK3KCNK9TOP1TOP2ATOP2B
SCHEMBL13881267 0.80 KMT2A (0.57) KCNK3KCNK9TOP1TOP2ATOP2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170157567-A1 SOLVENT RESISTANT POLYAMIDE NANOFILTRATION MEMBRANES IP2IPO INNOVATIONS LIMITED (GB) 2017-06-08 — — US disclosed
US-20130112619-A1 SOLVENT RESISTANT POLYAMIDE NANOFILTRATION MEMBRANES IMPERIAL INNOVATIONS LIMITED (GB) 2013-05-09 — — US disclosed
US-20130112619-A1 SOLVENT RESISTANT POLYAMIDE NANOFILTRATION MEMBRANES IMPERIAL INNOVATIONS LIMITED (GB) 2013-05-09 — — US disclosed
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