Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 4/20 | 0.64 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | WNT3A | P56704 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492683 | 0.89 | CNR1 (0.60) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492651 | 0.87 | PSEN1 (0.69) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492760 | 0.85 | CNR1 (0.66) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492664 | 0.85 | CNR1 (0.62) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492711 | 0.85 | CNR1 (0.62) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2183353 | 0.84 | PSEN1 (0.74) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492748 | 0.83 | PSEN1 (0.66) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492960 | 0.83 | CNR1 (0.66) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1493021 | 0.81 | CNR1 (0.60) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492661 | 0.81 | WNT3A (0.57) | CNR1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | claimed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | claimed |
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |