Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 13/20 | 0.66 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | WNT3A | P56704 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492651 | 0.89 | PSEN1 (0.69) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7964488 | 0.89 | ROCK2 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492798 | 0.88 | PSEN1 (0.72) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492664 | 0.88 | CNR1 (0.62) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492711 | 0.88 | CNR1 (0.62) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492960 | 0.86 | CNR1 (0.66) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492800 | 0.85 | CNR1 (0.64) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492734 | 0.84 | PSEN1 (0.66) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1493027 | 0.84 | CNR1 (0.69) | CNR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1493021 | 0.84 | CNR1 (0.60) | CNR1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | claimed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | claimed |