Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.54 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.54 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.54 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.54 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.54 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | IDH1 | O75874 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27809664 | 0.88 | GRM4 (0.57) | MEN1KMT2AMAPTPSEN1PSEN2 | |
| SCHEMBL1492788 | 0.88 | HTR2C (0.57) | MEN1KMT2AMAPTPSEN1PSEN2 | |
| SCHEMBL27809799 | 0.87 | PSEN1 (0.54) | MEN1KMT2AMAPTPSEN1PSEN2 | |
| SCHEMBL1493084 | 0.87 | MEN1 (0.58) | MEN1KMT2AMAPTPSEN1PSEN2 | |
| SCHEMBL1492820 | 0.84 | MAPT (0.65) | MEN1KMT2AMAPTPSEN1PSEN2 | |
| SCHEMBL1492687 | 0.83 | PORCN (0.60) | MEN1KMT2AMAPTPSEN1PSEN2 | |
| SCHEMBL1492989 | 0.83 | SMN1; SMN2 (0.62) | MEN1KMT2AMAPTPSEN1PSEN2 | |
| SCHEMBL1492881 | 0.83 | PSEN1 (0.56) | MEN1KMT2AMAPTPSEN1PSEN2 | |
| SCHEMBL1492835 | 0.83 | PSEN1 (0.57) | MEN1KMT2AMAPTPSEN1PSEN2 | |
| SCHEMBL1492785 | 0.81 | PSEN1 (0.57) | MEN1KMT2AMAPTPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083794-A | Urea compounds as gamma secretase modulators | AMGEN INC | 2011-06-01 | — | — | CN | claimed |
| US-20110118234-A1 | Urea Compounds as Gamma Secretase Modulators | AMGEN INC. | 2011-05-19 | — | — | US | claimed |
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | claimed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | claimed |
| US-20110118234-A1 | Urea Compounds as Gamma Secretase Modulators | AMGEN INC. | 2011-05-19 | — | — | US | disclosed |
| US-20110118234-A1 | Urea Compounds as Gamma Secretase Modulators | AMGEN INC. | 2011-05-19 | — | — | US | disclosed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118234-A1 | Urea Compounds as Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | MEN1 3122/4885KMT2A 3895/4885MAPT 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.