⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14946295 | 1.00 | — | — | |
| SCHEMBL14946290 | 0.90 | ALB (0.32) | — | |
| SCHEMBL24429180 | 0.89 | ALB (0.31) | — | |
| SCHEMBL14512789 | 0.86 | — | — | |
| SCHEMBL22855321 | 0.86 | — | — | |
| SCHEMBL14929428 | 0.82 | ADORA3 (0.37) | — | |
| SCHEMBL5992610 | 0.82 | ADORA3 (0.37) | — | |
| SCHEMBL4313984 | 0.82 | ADORA3 (0.37) | — | |
| SCHEMBL4313991 | 0.82 | ADORA3 (0.37) | — | |
| SCHEMBL19884354 | 0.81 | POLG (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170056528-A1 | MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF | MODERNATX, INC. | 2017-03-02 | — | — | US | disclosed |
| US-9428535-B2 | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof | MODERNA THERAPEUTICS, INC. (US) | 2016-08-30 | — | — | US | disclosed |
| US-20130115272-A1 | MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF | modeRNA Therapeutics (US) | 2013-05-09 | — | — | US | disclosed |