SCHEMBL14930469

SCHEMBL14930469

COCCOc1ccc(-c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH2 P25021 1/20 0.46
HRH1 P35367 1/20 0.46
CBFB Q13951 1/20 0.45
KIF11 P52732 1/20 0.45
SCN10A Q9Y5Y9 2/20 0.44
KCNH2 Q12809 1/20 0.44
PTGER4 P35408 1/20 0.43
MCHR1 Q99705 1/20 0.43
KDM4E B2RXH2 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
ABL1 P00519 1/20 0.42
SCN5A Q14524 2/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
FFAR1 O14842 2/20 0.42
FFAR4 Q5NUL3 2/20 0.42
HDAC3 O15379 2/20 0.41
HDAC4 P56524 2/20 0.41
HDAC1 Q13547 2/20 0.41
HDAC7 Q8WUI4 2/20 0.41
HDAC2 Q92769 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14930514 1.00 HRH2 (0.46) HRH2HRH1CBFBKIF11SCN10A
SCHEMBL14930445 0.86 ACACB (0.46) CBFBMCHR1KDM4ETDP1L3MBTL1
SCHEMBL13554406 0.84 CYP3A4 (0.50) MCHR1KDM4ECYP2C9MAPT
SCHEMBL2056313 0.84 HRH2 (0.50) HRH2HRH1KIF11PTGER4KDM4E
SCHEMBL14930472 0.82 KDM4E (0.46) KIF11KDM4EMAOB
SCHEMBL14930518 0.82 KDM4E (0.46) KIF11KDM4EMAOB
SCHEMBL12926315 0.82 KIF11 (0.45) KIF11SCN10AKDM4ETDP1MAOB
SCHEMBL14930528 0.81 CBFB (0.53) CBFBKDM4ETDP1ABL1FFAR1
SCHEMBL14232126 0.79 CYP2D6 (0.53) KDM4ETDP1L3MBTL1MAPT
SCHEMBL14926622 0.79 CYP2D6 (0.53) KDM4ETDP1L3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9939555-B2 Cinnamic acid derivative, polymer thereof, and liquid crystal alignment layer comprising cured product thereof DIC CORPORATION (JP) 2018-04-10 US disclosed
US-9708535-B2 Liquid crystal alignment layer DIC CORPORATION (JP) 2017-07-18 US disclosed
US-9684206-B2 Copolymer, and liquid crystal alignment layer including cured product thereof DIC CORPORATION (JP) 2017-06-20 US disclosed
US-20170088777-A1 LIQUID CRYSTAL ALIGNMENT LAYER DIC CORPORATION (JP) 2017-03-30 US disclosed
US-20160274418-A1 CINNAMIC ACID DERIVATIVE, POLYMER THEREOF, AND LIQUID CRYSTAL ALIGNMENT LAYER COMPRISING CURED PRODUCT THEREOF DIC CORPORATION (JP) 2016-09-22 US disclosed
US-9360708-B2 Cinnamic acid derivative, polymer thereof, and liquid crystal alignment layer comprising cured product thereof DIC CORPORATION (JP) 2016-06-07 US disclosed
US-9340634-B2 Polymer for use in liquid crystal alignment layer DIC CORPORATION (JP) 2016-05-17 US disclosed
US-20140221574-A1 COPOLYMER, AND LIQUID CRYSTAL ALIGNMENT LAYER INCLUDING CURED PRODUCT THEREOF DIC CORPORATION (JP) 2014-08-07 US disclosed
US-20140154428-A1 CINNAMIC ACID DERIVATIVE, POLYMER THEREOF, AND LIQUID CRYSTAL ALIGNMENT LAYER COMPRISING CURED PRODUCT THEREOF DIC CORPORATION (JP) 2014-06-05 US disclosed
US-20140121345-A1 CINNAMIC ACID DERIVATIVE, POLYMER THEREOF, AND LIQUID CRYSTAL ALIGNMENT LAYER COMPRISING CURED PRODUCT THEREOF DIC CORPORATION (JP) 2014-05-01 US disclosed
US-20130116396-A1 POLYMER FOR USE IN LIQUID CRYSTAL ALIGNMENT LAYER DIC CORPORATION (JP) 2013-05-09 US disclosed