Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14932724 | 0.89 | KCNH2 (0.39) | KCNH2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14902450 | 0.88 | KCNH2 (0.40) | KCNH2MEN1KMT2AL3MBTL1CYP4A11 | |
| SCHEMBL14932740 | 0.84 | LMNA (0.41) | MEN1KMT2AL3MBTL1CYP4A11ALDH1A1 | |
| SCHEMBL14902427 | 0.79 | JAK2 (0.49) | MEN1KMT2AL3MBTL1CYP4A11ALDH1A1 | |
| SCHEMBL14902435 | 0.78 | KCNH2 (0.48) | KCNH2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14902449 | 0.77 | KCNH2 (0.38) | KCNH2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14902434 | 0.77 | KCNH2 (0.50) | KCNH2MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL14902441 | 0.76 | NAMPT (0.51) | KCNH2CHRM4TPSAB1 | |
| SCHEMBL14902443 | 0.76 | SIGMAR1 (0.48) | KCNH2ALDH1A1LMNACHRM4 | |
| SCHEMBL14902442 | 0.75 | CHRM4 (0.46) | KCNH2MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773633-B1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2017-08-02 | — | — | EP | disclosed |
| WO-2013064450-A1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-10 | — | — | WO | disclosed |