Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16021936 | 0.88 | HDAC1 (0.36) | FAAHKMT2AALDH1A1SCN9APDPK1 | |
| SCHEMBL16021942 | 0.86 | FAAH (0.35) | FAAHKMT2AALDH1A1SCN9APDPK1 | |
| SCHEMBL14920522 | 0.83 | FAAH (0.40) | FAAHKMT2AALDH1A1SCN9AMEN1 | |
| SCHEMBL14933653 | 0.80 | PIM1 (0.38) | KMT2AALDH1A1PDPK1MEN1CSNK2A1 | |
| SCHEMBL14933657 | 0.80 | ESR1 (0.42) | FAAHKMT2AALDH1A1PDPK1MEN1 | |
| SCHEMBL16011441 | 0.78 | MAP2K4 (0.39) | PDPK1MAPT | |
| SCHEMBL14919956 | 0.78 | MAPT (0.32) | KMT2APDPK1MEN1MAPTALOX15 | |
| SCHEMBL1759441 | 0.77 | MAPT (0.46) | FAAHMAPTLMNA | |
| SCHEMBL16022001 | 0.77 | HDAC3 (0.40) | SCN9APDPK1 | |
| SCHEMBL8265372 | 0.76 | SOS1 (0.39) | FAAHKMT2AALDH1A1PDPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773641-B1 | BIARYL ETHER SULFONAMIDES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2017-09-27 | — | — | EP | disclosed |
| WO-2013064984-A1 | BIARYL ETHER SULFONAMIDES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2013-05-10 | — | — | WO | disclosed |