Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493487 | 0.90 | ALDH1A1 (0.79) | ALDH1A1MAPK1POLBABCB1SMN1; SMN2 | |
| SCHEMBL1493466 | 0.85 | ALDH1A1 (0.72) | ALDH1A1MAPK1POLBABCB1SMN1; SMN2 | |
| SCHEMBL1611509 | 0.85 | ALDH1A1 (0.69) | ALDH1A1MAPK1POLBABCB1SMN1; SMN2 | |
| SCHEMBL1611340 | 0.80 | POLB (0.59) | ALDH1A1MAPK1POLBABCB1SMN1; SMN2 | |
| SCHEMBL859415 | 0.80 | ALDH1A1 (0.74) | ALDH1A1MAPK1POLBSMN1; SMN2MAPT | |
| SCHEMBL1493311 | 0.80 | ALDH1A1 (0.76) | ALDH1A1MAPK1POLBSMN1; SMN2HPGD | |
| SCHEMBL1611721 | 0.80 | LMNA (0.76) | ALDH1A1MAPK1POLBSMN1; SMN2HSD17B10 | |
| SCHEMBL1493472 | 0.79 | POLB (0.68) | ALDH1A1MAPK1POLBMAPTHPGD | |
| SCHEMBL1493435 | 0.79 | ALDH1A1 (0.79) | ALDH1A1MAPK1POLBABCB1SMN1; SMN2 | |
| SCHEMBL1493362 | 0.79 | MAPK1 (0.78) | ALDH1A1MAPK1POLBMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086889-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-04-14 | — | — | US | disclosed |
| EP-2288603-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2011-03-02 | — | — | EP | disclosed |
| WO-2009150614-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086889-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY1R | ALDH1A1 3233/4885MAPK1 3086/4885POLB 4782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.