⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30838764 | 1.00 | — | — | |
| SCHEMBL27957344 | 1.00 | PLAU (0.47) | — | |
| SCHEMBL3603993 | 0.79 | — | — | |
| SCHEMBL30297014 | 0.79 | — | — | |
| SCHEMBL362099 | 0.79 | — | — | |
| SCHEMBL14934142 | 0.77 | MKNK1 (0.45) | — | |
| SCHEMBL362876 | 0.75 | — | — | |
| SCHEMBL14145438 | 0.75 | — | — | |
| SCHEMBL20969344 | 0.75 | — | — | |
| SCHEMBL892755 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 434 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935239-B1 | PROCESS FOR PREPARING 4-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLORO-1-OXIDO-4-PYRIDYL)-5-METHOXYPYRIDINE-2-CARBOXAMIDE | SANOFI SA (FR) | 2018-08-29 | — | — | EP | claimed |
| CN-106632013-A | 2-amino-3,5-dichloro-1-(2-(4-bromophenyl)-2-oxoethyl)pyridinium bromide | 山东友帮生化科技有限公司 | 2017-05-10 | — | — | CN | claimed |
| CN-106117133-A | A kind of preparation method of roflumilast process contaminants | 成都欣捷高新技术开发股份有限公司 | 2016-11-16 | — | — | CN | claimed |
| CN-106008329-A | Preparation method of 5-chloro-2,3-difluoropyridine | 维讯化工（南京）有限公司 | 2016-10-12 | — | — | CN | claimed |
| EP-2935239-A1 | PROCESS FOR PREPARING 4-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLORO-1-OXIDO-4-PYRIDYL)-5-METHOXYPYRIDINE-2-CARBOXAMIDE | SANOFI (FR) | 2015-10-28 | — | — | EP | claimed |
| CN-104016908-A | Synthetic method of 2-amino-3,5-dichloropyridine | DINGTAO COUNTY YOUBANG CHEMICAL INDUSTRY CO LTD | 2014-09-03 | — | — | CN | claimed |
| WO-2014083106-A1 | PROCESS FOR PREPARING 4-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLORO-1-OXIDO-4-PYRIDYL)-5-METHOXYPYRIDINE-2-CARBOXAMIDE | SANOFI (FR) | 2014-06-05 | — | — | WO | claimed |
| CN-102942521-A | Preparation method of roflumilast | SICHUAN KELUN PHARM RES CO LTD | 2013-02-27 | — | — | CN | claimed |
| JP-4742026-B2 | — | — | 2011-08-10 | — | — | JP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1325006-A2 | HETEROCYCLIC COMPOUNDS AS LIGANDS OF THE GABA A? RECEPTOR | NEUROGEN CORPORATION (US) | 2003-07-09 | — | — | EP | claimed |
| US-20030105081-A1 | Heterocyclic compounds as ligands of the GABAA receptor | PFIZER INC | 2003-06-05 | — | — | US | claimed |
| WO-2002012442-A2 | HETEROCYCLIC COMPOUNDS AS LIGANDS OF THE GABAA RECEPTOR | NEUROGEN CORPORATION (US) | 2002-02-14 | — | — | WO | claimed |
| US-6176909-B1 | IN POLYMERIC BINDER | XEROX CORPORATION | 2001-01-23 | — | — | US | claimed |
| EP-0128563-B1 | IMPROVED ANTIFOGGANT PROCESS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-04-04 | — | — | EP | claimed |
| EP-0128563-A2 | Improved antifoggant process | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-12-19 | — | — | EP | claimed |
| US-4468454-A | NEGATIVE SILVER HALIDE EMULSIONS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-08-28 | — | — | US | claimed |
| EP-0045570-B1 | USE OF ORGANIC HALOGEN COMPOUNDS TO REDUCE OR PREVENT FOG IN NEGATIVE-WORKING SILVER HALIDE EMULSIONS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-09-28 | — | — | EP | claimed |
| US-4323645-A | Organic halogen compounds for negative-working silver halide emulsions | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-04-06 | — | — | US | claimed |
| EP-0045570-A1 | Use of organic halogen compounds to reduce or prevent fog in negative-working silver halide emulsions | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-02-10 | — | — | EP | claimed |