Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14934268 | 0.87 | PARP1 (0.51) | PARP1HCAR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14934266 | 0.85 | PARP1 (0.52) | PARP1HCAR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15208952 | 0.84 | PARP1 (0.64) | PARP1HCAR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14934267 | 0.83 | PARP1 (0.50) | PARP1HCAR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14934251 | 0.82 | PARP1 (0.57) | PARP1HCAR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27901177 | 0.81 | PARP1 (0.69) | PARP1HCAR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14934239 | 0.80 | HCAR3 (0.41) | HCAR3MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL14934242 | 0.78 | PARP1 (0.54) | PARP1HCAR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14934253 | 0.78 | PARP1 (0.54) | PARP1HCAR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14934263 | 0.77 | PARP1 (0.55) | PARP1HCAR3KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103086925-A | Benzoyl urea derivatives having anticancer activity and their preparation method and use | ZHEJIANG HISUN PHARM CO LTD | 2013-05-08 | — | — | CN | claimed |
| WO-2013064029-A1 | BENZOYLUREA DERIVATIVE WITH ANTICANCER ACTIVITY AND PREPARATION METHOD AND USE THEREOF | 浙江海正药业股份有限公司 (CN) | 2013-05-10 | — | — | WO | disclosed |
| CN-103086925-A | Benzoyl urea derivatives having anticancer activity and their preparation method and use | ZHEJIANG HISUN PHARM CO LTD | 2013-05-08 | — | — | CN | disclosed |