Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11915104 | 0.82 | ALDH1A1 (0.44) | POLBSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL5177288 | 0.79 | ALDH1A1 (0.50) | POLBSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL6151739 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL27610729 | 0.79 | POLB (0.47) | POLBSMN1; SMN2LMNAHTTIDO1 | |
| SCHEMBL5540345 | 0.79 | LMNA (0.50) | POLBSMN1; SMN2LMNAHTTIDO1 | |
| SCHEMBL3417466 | 0.79 | ALDH1A1 (0.66) | POLBSMN1; SMN2LMNAHTTIDO1 | |
| SCHEMBL9014506 | 0.79 | SMN1; SMN2 (0.39) | POLBSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL8048128 | 0.78 | ALDH1A1 (0.49) | POLBSMN1; SMN2LMNAHTTIDO1 | |
| Hydrochloric Acid SCHEMBL8020291 | 0.78 | ALDH1A1 (0.49) | POLBSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL55213 | 0.77 | ALDH1A1 (0.53) | POLBSMN1; SMN2LMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102056920-A | Tetrazole compounds as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2011-05-11 | — | — | CN | disclosed |
| US-20110086889-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-04-14 | — | — | US | disclosed |
| EP-2288603-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2011-03-02 | — | — | EP | disclosed |
| WO-2009150614-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-12-17 | — | — | WO | disclosed |
| CN-1154366-A | Tetrazole oxyacetamides | BAYER AGROCHEM KK (JP) | 1997-07-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086889-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY1R | POLB 4782/4885SMN1; SMN2 4215/4885LMNA 4145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.