Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 17/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 17/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 17/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 17/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 17/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 17/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 17/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 16/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 16/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.63 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | BRD4 | O60885 | 1/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14934830 | 0.98 | HDAC4 (0.67) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL14934838 | 0.98 | HDAC4 (0.67) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL14934660 | 0.98 | HDAC4 (0.67) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL11162134 | 0.95 | CYP3A4 (0.71) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL517309 | 0.86 | HDAC4 (0.81) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL15675744 | 0.85 | CYP3A4 (0.66) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1065393 | 0.84 | HDAC4 (0.85) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL137348 | 0.84 | HDAC4 (0.85) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL6669511 | 0.84 | HDAC4 (0.85) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL6665592 | 0.84 | HDAC4 (0.85) | HDAC4HDAC1HDAC7HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |