Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4510850 | 0.80 | GAA (0.48) | GRM2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL16466966 | 0.79 | GAA (0.49) | GRM2GAADRD4SMN1; SMN2DRD2 | |
| SCHEMBL4719277 | 0.77 | DRD4 (0.46) | GRM2GAADRD4SMN1; SMN2DRD2 | |
| SCHEMBL2016909 | 0.76 | GAA (0.49) | GRM2GAAALDH1A1MMP1MMP3 | |
| SCHEMBL29079618 | 0.75 | GRM2 (0.50) | GRM2GAADRD4SMN1; SMN2MEN1 | |
| SCHEMBL537663 | 0.75 | GRM2 (0.50) | GRM2GAADRD4SMN1; SMN2MEN1 | |
| SCHEMBL8562128 | 0.74 | GAA (0.56) | GRM2GAASMN1; SMN2ALDH1A1MMP1 | |
| SCHEMBL8562132 | 0.74 | GAA (0.56) | GRM2GAASMN1; SMN2ALDH1A1MMP1 | |
| SCHEMBL5638987 | 0.74 | GAA (0.49) | GRM2GAAALDH1A1MMP1MMP3 | |
| SCHEMBL3264320 | 0.74 | GAA (0.52) | GRM2GAAALDH1A1MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9498483-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2016-11-22 | — | — | US | disclosed |
| US-20150224109-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | NOVARTIS AG (CH) | 2015-08-13 | — | — | US | disclosed |
| US-9040690-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2015-05-26 | — | — | US | disclosed |
| US-20130123252-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150224109-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | TPMT, CYP3A5, CYP11B2 | GRM2 2108/4885GAA 428/4885DRD4 1960/4885 |
| US-20130123252-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | TPMT, CYP3A5, CYP11B2 | GRM2 2108/4885GAA 428/4885DRD4 1960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.