SCHEMBL14935535

SCHEMBL14935535

Brc1cccc([Si](c2ccccc2)(c2ccccc2)c2ccc3c4ccccc4c4ccccc4c3c2)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 3/20 0.36
ABCB1 P08183 1/20 0.36
EGFR P00533 4/20 0.36
EPAS1 Q99814 1/20 0.36
ALDH1A1 P00352 4/20 0.35
MEN1 O00255 4/20 0.35
KMT2A Q03164 4/20 0.35
KDM4E B2RXH2 1/20 0.35
NPC1 O15118 1/20 0.35
TP53 P04637 1/20 0.35
TSHR P16473 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
TDP1 Q9NUW8 1/20 0.34
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33
ALOX12 P18054 1/20 0.33
MAPT P10636 1/20 0.33
APP P05067 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17083516 0.89 ALDH1A1 (0.37) ABCG2ALDH1A1MEN1KMT2ANPC1
SCHEMBL4300967 0.87 ALDH1A1 (0.46) ABCG2ABCB1EGFRALDH1A1MEN1
SCHEMBL31167613 0.87 ALDH1A1 (0.46) ABCG2ABCB1EGFRALDH1A1MEN1
SCHEMBL5919703 0.87 ALDH1A1 (0.46) ABCG2ABCB1EGFRALDH1A1MEN1
SCHEMBL13043040 0.87 HPRT1 (0.35) ALDH1A1KDM4ESMN1; SMN2TDP1HPGD
SCHEMBL14948294 0.87 HPRT1 (0.35) ALDH1A1KDM4ESMN1; SMN2TDP1HPGD
SCHEMBL13766231 0.87 HPRT1 (0.35) ALDH1A1KDM4ESMN1; SMN2TDP1HPGD
SCHEMBL25056770 0.81 ALDH1A1 (0.46) ABCG2ABCB1ALDH1A1MEN1KMT2A
SCHEMBL27213461 0.81 IDO1 (0.45) ABCG2EGFRALDH1A1MEN1KMT2A
SCHEMBL4876931 0.80 ALDH1A1 (0.46) ALDH1A1MEN1KMT2AKDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9142788-B2 Host materials for OLEDs UNIVERSAL DISPLAY CORPORATION (US) 2015-09-22 US disclosed
US-9142788-B2 Host materials for OLEDs UNIVERSAL DISPLAY CORPORATION (US) 2015-09-22 US disclosed
US-9142788-B2 Host materials for OLEDs UNIVERSAL DISPLAY CORPORATION (US) 2015-09-22 US disclosed
US-20140117343-A1 HOST MATERIALS FOR OLEDS UNIVERSAL DISPLAY CORPORATION (US) 2014-05-01 US disclosed
US-8652656-B2 Triphenylene silane hosts UNIVERSAL DISPLAY CORPORATION (US) 2014-02-18 US disclosed
US-8652656-B2 Triphenylene silane hosts UNIVERSAL DISPLAY CORPORATION (US) 2014-02-18 US disclosed
US-8652656-B2 Triphenylene silane hosts UNIVERSAL DISPLAY CORPORATION (US) 2014-02-18 US disclosed
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS UNIVERSAL DISPLAY CORPORATION (US) 2013-05-16 US disclosed
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS UNIVERSAL DISPLAY CORPORATION (US) 2013-05-16 US disclosed
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS UNIVERSAL DISPLAY CORPORATION (US) 2013-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS OCIAD2, OCIAD1, YAP1 ABCG2 2071/4885ABCB1 1274/4885EGFR 3019/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.