Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.41 |
| ▸ | INSR | P06213 | 4/20 | 0.36 |
| ▸ | ROS1 | P08922 | 5/20 | 0.36 |
| ▸ | MET | P08581 | 3/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15207525 | 0.82 | ALK (0.37) | ALKINSRROS1METEGFR | |
| SCHEMBL11916576 | 0.74 | ALK (0.70) | ALKINSRROS1METEGFR | |
| SCHEMBL21715308 | 0.74 | ALK (0.60) | ALKINSRROS1METPTK2 | |
| SCHEMBL1491742 | 0.71 | ALK (0.45) | ALKINSRROS1PTK2 | |
| SCHEMBL18338691 | 0.70 | ALK (0.39) | ALKINSRROS1METPTK2 | |
| SCHEMBL1491819 | 0.69 | SIGMAR1 (0.47) | — | |
| SCHEMBL3960785 | 0.68 | ALK (0.42) | ALKINSR | |
| SCHEMBL11916442 | 0.67 | ALK (0.73) | ALKINSRROS1EGFR | |
| SCHEMBL22494176 | 0.66 | ALK (0.37) | ALKINSREGFR | |
| SCHEMBL1376839 | 0.66 | ZAP70 (0.47) | ALKINSRROS1METPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300013-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD Pharmaceuticals, Inc (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009143389-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |