Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.47 |
| ▸ | EGFR | P00533 | 8/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.44 |
| ▸ | INSR | P06213 | 6/20 | 0.44 |
| ▸ | IGF1R | P08069 | 6/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | STK25 | O00506 | 1/20 | 0.42 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | CASK | O14936 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.42 |
| ▸ | MUSK | O15146 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21715308 | 0.83 | ALK (0.60) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL29015712 | 0.76 | EGFR (0.49) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL5768606 | 0.76 | ZAP70 (0.77) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL29015781 | 0.74 | ALK (0.47) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL375779 | 0.71 | ZAP70 (0.54) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL12780500 | 0.71 | ZAP70 (0.70) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL14857729 | 0.70 | ALK (0.61) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL26092640 | 0.69 | INSR (0.84) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL1061877 | 0.68 | ALK (0.72) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL12728763 | 0.68 | ZAP70 (0.64) | ZAP70EGFRALKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4796487-B2 | — | — | 2011-10-19 | — | — | JP | claimed |
| EP-1606265-A1 | 2, 4- DI (PHENYLAMINO) PYRIMIDINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | Novartis AG (CH) | 2005-12-21 | — | — | EP | claimed |
| WO-2004080980-A1 | 2, 4- DI (PHENYLAMINO) PYRIMIDINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2004-09-23 | — | — | WO | claimed |