SCHEMBL14936722

SCHEMBL14936722

CN(c1cc(O)cc(O)c1)c1nc2cc(-c3cc(O)ccc3Cl)ccn2n1

nearest known ligand 0.35

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SRC P12931 2/20 0.35
PDGFRB P09619 1/20 0.32
ABL1 P00519 1/20 0.30
PDE2A O00408 2/20 0.30
PDE10A Q9Y233 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14936950 0.84 PIK3CG (0.36) SRCPDGFRBABL1PDE2APDE10A
SCHEMBL41638 0.76 PIK3CG (0.43) SRCPDE2APDE10A
SCHEMBL14936919 0.74 PIK3CG (0.40) SRCPDGFRBABL1
SCHEMBL14937276 0.73 PIK3CG (0.34) SRCPDGFRB
SCHEMBL14936042 0.72 FGFR4 (0.43) SRCPDGFRBABL1PDE2APDE10A
SCHEMBL14936009 0.72 PIK3CG (0.35) SRCPDGFRBABL1PDE2APDE10A
SCHEMBL14937044 0.72 PIK3CG (0.33) SRCPDGFRBABL1PDE2APDE10A
SCHEMBL14936723 0.70 SRC (0.39) SRC
SCHEMBL14936318 0.63 FGFR4 (0.41) SRCPDGFRBABL1PDE2APDE10A
SCHEMBL31507885 0.61 TDP2 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130123271-A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THERAPEUTIC APPLICATION FOVEA PHARMACEUTICALS (FR) 2013-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123271-A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THERAPEUTIC APPLICATION CAMK2D, CAMK2A, CAMK2B SRC 401/4885PDGFRB 803/4885ABL1 181/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.