Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774235 | 0.92 | HSD17B10 (0.51) | MAPTHPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL10036380 | 0.85 | MAPT (0.58) | MAPTHPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL3538406 | 0.84 | HSD17B10 (0.53) | MAPTHPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL21331700 | 0.84 | MAPT (0.60) | MAPTHPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL10036151 | 0.83 | HSD17B10 (0.51) | MAPTHPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL1663340 | 0.83 | CYP19A1 (0.59) | MAPTHPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL12952804 | 0.82 | CYP19A1 (0.62) | MAPTHPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL2910058 | 0.82 | MAPT (0.54) | MAPTHPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL31534614 | 0.81 | RAB9A (0.55) | MAPTHPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL1929875 | 0.81 | MAPT (0.60) | MAPTHPGDRAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877752-B2 | 4(1H)-quinolones having antimalarial activity with reduced chemical resistance | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-11-04 | — | — | US | disclosed |
| US-20130123258-A1 | 4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123258-A1 | 4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance | CDC25C, ABCC1, CDC25A | MAPT 3255/4885HPGD 757/4885RAB9A 1024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.