Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 9/20 | 0.41 |
| ▸ | DRD3 | P35462 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14940461 | 0.84 | NPSR1 (0.62) | NPSR1SMN1; SMN2HSD17B10DRD2ALDH1A1 | |
| SCHEMBL14939130 | 0.84 | NPSR1 (0.47) | NPSR1DRD4DRD3DRD2MAPT | |
| SCHEMBL14939113 | 0.83 | NPSR1 (0.53) | NPSR1KDM4EALDH1A1PARP1 | |
| SCHEMBL14939131 | 0.81 | KMT2A (0.46) | NPSR1HTTKDM4EALDH1A1MAPT | |
| SCHEMBL14940522 | 0.81 | NPSR1 (0.53) | NPSR1SMN1; SMN2HSD17B10DRD2HTT | |
| SCHEMBL14939607 | 0.81 | NPSR1 (0.53) | NPSR1DRD4DRD2HTTKDM4E | |
| SCHEMBL14939717 | 0.80 | NPSR1 (0.46) | NPSR1SMN1; SMN2HSD17B10HTTKDM4E | |
| SCHEMBL14939434 | 0.80 | NPSR1 (0.51) | NPSR1HTTKDM4EALDH1A1MAPT | |
| SCHEMBL14939834 | 0.79 | NPSR1 (0.53) | NPSR1DRD4DRD3DRD2KDM4E | |
| SCHEMBL14939051 | 0.79 | NPSR1 (0.50) | NPSR1DRD2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |