Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | DAO | P14920 | 1/20 | 0.67 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.67 |
| ▸ | CES1 | P23141 | 4/20 | 0.56 |
| ▸ | CES2 | O00748 | 3/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL998372 | 0.90 | TSHR (0.63) | TSHRDAONAPRTCES1CES2 | |
| Isophthalic Acid SCHEMBL1000200 | 0.86 | CYP1A2 (0.61) | TSHRDAONAPRTHSD17B10HPGD | |
| Benzoic Acid SCHEMBL3044510 | 0.82 | TSHR (0.88) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL6869498 | 0.82 | TSHR (0.88) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL149318 | 0.82 | TSHR (1.00) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL975929 | 0.82 | TSHR (1.00) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL3966600 | 0.82 | TSHR (1.00) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL7719037 | 0.82 | TSHR (1.00) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL137419 | 0.82 | TSHR (1.00) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL407365 | 0.82 | TSHR (1.00) | TSHRDAONAPRTCES1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10344261-B2 | Immunomodulatory conjugates | ASCEND BIOPHARMACEUTICALS LTD (AU) | 2019-07-09 | — | — | US | disclosed |
| CN-104661683-A | Immunomodulatory conjugates | ASCEND BIOPHARMACEUTICALS PTY LTD | 2015-05-27 | — | — | CN | disclosed |
| US-20150030626-A1 | IMMUNOMODULATORY CONJUGATES | Ascend Biopharamaceuticals Ltd (AU) | 2015-01-29 | — | — | US | disclosed |
| EP-2776070-A1 | IMMUNOMODULATORY CONJUGATES | Ascend Biopharmaceuticals Ltd (AU) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013067597-A1 | IMMUNOMODULATORY CONJUGATES | ASCEND BIOPHARMACEUTICALS PTY LTD (AU) | 2013-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10344261-B2 | Immunomodulatory conjugates | CLEC4M, TLR3, CD74 | TSHR 4346/4885DAO 4495/4885NAPRT 873/4885 |
| US-20150030626-A1 | IMMUNOMODULATORY CONJUGATES | CLEC4M, TLR3, CD74 | TSHR 4346/4885DAO 4495/4885NAPRT 873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.