SCHEMBL14939162

SCHEMBL14939162

COc1cccc(CN2CCN(C3(c4cncc(C)n4)C(=O)c4ccccc4C3=O)CC2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.51
NPSR1 Q6W5P4 1/20 0.50
ALDH1A1 P00352 6/20 0.48
ALDH3A1 P30838 1/20 0.48
CASP1 P29466 1/20 0.46
CASP4 P49662 1/20 0.46
CASP5 P51878 1/20 0.46
KDM4E B2RXH2 5/20 0.45
GAA P10253 3/20 0.45
HTR1A P08908 2/20 0.45
DRD2 P14416 1/20 0.45
HTR2B P41595 1/20 0.45
FAAH O00519 1/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
GFER P55789 1/20 0.43
CHRM2 P08172 1/20 0.43
CHRM3 P20309 1/20 0.43
HTR1D P28221 1/20 0.43
HTR1B P28222 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14940447 0.89 SIGMAR1 (0.54) SIGMAR1NPSR1ALDH1A1ALDH3A1CASP1
SCHEMBL14940011 0.87 NPSR1 (0.66) SIGMAR1NPSR1ALDH1A1GAADRD2
SCHEMBL14940134 0.85 SIGMAR1 (0.51) SIGMAR1NPSR1ALDH1A1ALDH3A1CASP1
SCHEMBL14939458 0.84 NPSR1 (0.52) SIGMAR1NPSR1ALDH1A1ALDH3A1KDM4E
SCHEMBL14939713 0.84 NPSR1 (0.65) SIGMAR1NPSR1ALDH1A1ALDH3A1KDM4E
SCHEMBL14940106 0.84 NPSR1 (0.72) SIGMAR1NPSR1ALDH1A1ALDH3A1KDM4E
SCHEMBL14940026 0.84 NPSR1 (0.56) SIGMAR1NPSR1ALDH1A1ALDH3A1KDM4E
SCHEMBL14939758 0.83 NPSR1 (0.63) SIGMAR1NPSR1ALDH1A1ALDH3A1KDM4E
SCHEMBL14939172 0.83 NPSR1 (0.53) SIGMAR1NPSR1ALDH1A1ALDH3A1KDM4E
SCHEMBL14940056 0.83 SIGMAR1 (0.56) SIGMAR1NPSR1ALDH1A1ALDH3A1CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013068785-A1 INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS ACTELION PHARMACEUTICALS LTD (CH) 2013-05-16 WO claimed
WO-2013068785-A1 INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS ACTELION PHARMACEUTICALS LTD (CH) 2013-05-16 WO disclosed