Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939688 | 0.92 | NPSR1 (0.77) | NPSR1MAPTMMP2MMP9LMNA | |
| SCHEMBL14938982 | 0.90 | NPSR1 (0.64) | NPSR1MAPTMMP2MMP9LMNA | |
| SCHEMBL14939529 | 0.88 | NPSR1 (0.64) | NPSR1MAPTMMP2MMP9TSHR | |
| SCHEMBL14939097 | 0.88 | NPSR1 (0.64) | NPSR1MAPTMMP2MMP9TSHR | |
| SCHEMBL14939742 | 0.84 | NPSR1 (0.82) | NPSR1MAPTMMP2MMP9TSHR | |
| SCHEMBL14939436 | 0.82 | NPSR1 (0.61) | NPSR1MAPTMMP2MMP9TSHR | |
| SCHEMBL14939299 | 0.82 | NPSR1 (0.58) | NPSR1MAPTLMNAKDM4ETDP1 | |
| SCHEMBL14939649 | 0.82 | NPSR1 (0.63) | NPSR1MAPTTSHRLMNATP53 | |
| SCHEMBL14939372 | 0.82 | NPSR1 (0.63) | NPSR1MAPTMMP2MMP9TSHR | |
| SCHEMBL14939562 | 0.80 | NPSR1 (0.60) | NPSR1MAPTTP53KDM4EOPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |