Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14938959 | 0.89 | NPSR1 (0.48) | NPSR1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL14939710 | 0.87 | NPSR1 (0.46) | NPSR1ALDH1A1DRD4KMT2AMEN1 | |
| SCHEMBL14939604 | 0.87 | NPSR1 (0.46) | NPSR1KDM4EALDH1A1DRD2DRD4 | |
| SCHEMBL14938910 | 0.87 | NPSR1 (0.46) | NPSR1KDM4EALDH1A1DRD2DRD4 | |
| SCHEMBL14939831 | 0.87 | NPSR1 (0.51) | NPSR1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL14939437 | 0.86 | ALDH1A1 (0.48) | NPSR1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL14939412 | 0.84 | NPSR1 (0.70) | NPSR1DRD2OPRM1SIGMAR1 | |
| SCHEMBL14939940 | 0.84 | NPSR1 (0.47) | NPSR1KMT2ACYP2D6LMNAMAPT | |
| SCHEMBL14939130 | 0.84 | NPSR1 (0.47) | NPSR1DRD2DRD4DRD3KMT2A | |
| SCHEMBL14939356 | 0.83 | NPSR1 (0.58) | NPSR1KDM4EALDH1A1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |